Artificial Intelligence Improves Drug Combination Design | Digital Science

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AI Improves Drug Combination Design

Harnessing Artificial Intelligence to Improve Drug Combination Design and Personalized Medicine. Credit: Zac Goh

A new auto-commentary published in SLAS Technology looks at how an emerging area of , specifically the analysis of small systems-of-interest specific datasets, can be used to improve development and personalized medicine. The auto-commentary builds on a study recently published by the authors in Science Translational Medicine about an artificial intelligence (AI) , Quadratic Phenotypic Optimization Platform (QPOP), that substantially therapy in bortezomib-resistant multiple myeloma to identify the best combinations for individual multiple myeloma patients.

It is now evident that complex diseases, such as , often require effective drug combinations to make any significant therapeutic impact. As the drugs in these combination therapies become increasingly specific to molecular targets, designing effective drug combinations as well as choosing the right drug combination for the right patient becomes more difficult.

Artificial intelligence is having a positive impact on drug development and personalized medicine. With the ability to efficiently analyze small datasets that focus on the specific disease of interest, QPOP and other small dataset-based AI platforms can rationally optimal drug combinations that are effective and based on real experimental data and not mechanistic assumptions or predictive modeling. Furthermore, because of the efficiency of the platform, QPOP can also be applied towards precious patient samples to help optimize and personalize combination therapy.

Publication: Masturah Bte Mohd Abdul Rashid, et al., “Artificial Intelligence- Designer Drug Combinations: From Drug Development to Personalized Medicine,” SLAS Technology, 2018; doi:10.1177/2472630318800774

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